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MICA Produits

(MHC Class I Polypeptide-Related Sequence A (MICA))

Catégories

MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010].

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Catégories MICA en vedette

MICA Anticorps

High quality antibodies with extensive validation data.

MICA Kits ELISA

Reliable ELISA kits for a wide range of species.

MICA Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

MICA recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, FACS, IF, IHC (p)
Validations
  • (2)
  • (7)
N° du produit ABIN652566
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, FACS, IP
Validations
  • (3)
  • (3)
N° du produit ABIN94329
Quantité 0.1 mg
Fiche technique Fiche technique
Reactivity Cat, Cow, Human, Non-Human Primate
Application ELISA, FACS, IP, ICC, IHC (fro), CyTOF
Validations
  • (9)
  • (3)
N° du produit ABIN2749085
Quantité 0.1 mg
Fiche technique Fiche technique

MICA recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6968602
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN411398
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
N° du produit ABIN6386157
Quantité 96 tests
Fiche technique Fiche technique

MICA recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
N° du produit ABIN7275256
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
N° du produit ABIN7275255
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (3)
N° du produit ABIN7275254
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits MICA

Srpan, Ambrose, Karampatzakis, Saeed, Cartwright, Guldevall, De Matos, Önfelt, Davis: "Shedding of CD16 disassembles the NK cell immune synapse and boosts serial engagement of target cells." dans: The Journal of cell biology, Vol. 217, Issue 9, pp. 3267-3283, (2018) (PubMed).

Chen, Zhidan, Xia, Zhaoxia, Qing, Qiang, Haipeng, Hengxiao: "Scorpion venom activates natural killer cells in hepatocellular carcinoma via the NKG2D-MICA pathway." dans: International immunopharmacology, Vol. 35, pp. 307-14, (2016) (PubMed).

Zanetti, Ziblat, Torres, Zwirner, Bouzat: "Expression and Functional Role of α7 Nicotinic Receptor in Human Cytokine-stimulated Natural Killer (NK) Cells." dans: The Journal of biological chemistry, Vol. 291, Issue 32, pp. 16541-52, (2016) (PubMed).

Tyciakova, Matuskova, Bohovic, Polakova, Toro, Skolekova, Kucerova: "Genetically engineered mesenchymal stromal cells producing TNF? have tumour suppressing effect on human melanoma xenograft." dans: The journal of gene medicine, (2015) (PubMed).

Shi, Li, Couturier, Yang, Guo, He, Lewis, Zhou: "Allele Specific Expression of MICA Variants in Human Fibroblasts Suggests a Pathogenic Mechanism." dans: The open rheumatology journal, Vol. 9, pp. 60-4, (2015) (PubMed).

Taniguchi, Koyano, Suzutani, Goishi, Ito, Morioka, Nakamura, Yamada, Oka, Inoue: "A Thr72Ala polymorphism in the NKG2D gene is associated with early symptomatic congenital cytomegalovirus disease." dans: Infection, Vol. 43, Issue 3, pp. 353-9, (2015) (PubMed).

Xiang, Liu, Zheng, Liu, Lv, Gao, Hu, Lam, Chan, Yang, Chen, Tsao, Bonneville, Lau, Tu: "Targeted activation of human V?9V?2-T cells controls epstein-barr virus-induced B cell lymphoproliferative disease." dans: Cancer cell, Vol. 26, Issue 4, pp. 565-76, (2014) (PubMed).

Umebayashi, Kiyota, Koya, Tanaka, Onishi, Katano, Morisaki: "An epithelial cell adhesion molecule- and CD3-bispecific antibody plus activated T-cells can eradicate chemoresistant cancer stem-like pancreatic carcinoma cells in vitro." dans: Anticancer research, Vol. 34, Issue 8, pp. 4509-19, (2014) (PubMed).

Morisaki, Hirano, Koya, Kiyota, Tanaka, Umebayashi, Onishi, Katano: "NKG2D-directed cytokine-activated killer lymphocyte therapy combined with gemcitabine for patients with chemoresistant metastatic solid tumors." dans: Anticancer research, Vol. 34, Issue 8, pp. 4529-38, (2014) (PubMed).

Gómez-Lomelí, Bravo-Cuellar, Hernández-Flores, Jave-Suárez, Aguilar-Lemarroy, Lerma-Díaz, Domínguez-Rodríguez, Sánchez-Reyes, Ortiz-Lazareno: "Increase of IFN-γ and TNF-α production in CD107a + NK-92 cells co-cultured with cervical cancer cell lines pre-treated with the HO-1 inhibitor." dans: Cancer cell international, Vol. 14, Issue 1, pp. 100, (2014) (PubMed).

Synonymes et noms alternatifs relatifs à MICA

MHC class I polypeptide-related sequence A (MICA), MIC-A, PERB11.1

Protein level used designations for MICA

  • HLA class I antigen
  • MHC class I chain-related protein A
  • stress inducible class I homolog
  • F10 alpha chain-like
  • class I histocompatibility antigen
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