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MKNK2 Protéines

(MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))

This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011].

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MKNK2 Protein (AA 1-459) (His tag)

custom-made MKNK2 Origine: Souris Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Mouse Recombinant Mknk2 Protein, UniprotID Q8CDB0

3 images

N° du produit ABIN7564540

Détails

MKNK2 Protein (AA 1-465) (His tag)

custom-made MKNK2 Origine: Humain Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Human Recombinant MKNK2 Protein, UniprotID Q9HBH9

3 images

N° du produit ABIN7554562

Détails

MKNK2 Protein (AA 1-158) (GST tag)

MKNK2 Origine: Humain Hôte: Wheat germ Recombinant ELISA, WB, AP, AA

Image no. 1 for MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) (AA 1-158) protein (GST tag) (ABIN1310978)

1 image

N° du produit ABIN1310978

Détails

MKNK2 Protein (GST tag)

MKNK2 Origine: Humain Hôte: Cellules d'insectes Recombinant 70 % - 90 % Func Active

N° du produit ABIN5509021

Détails

MKNK2 Protein (His tag)

MKNK2 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant ELISA, WB, SDS

N° du produit ABIN7578192

Détails

MKNK2 Protein (AA 1-459) (Strep Tag)

custom-made MKNK2 Origine: Souris Hôte: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, WB, SDS

N° du produit ABIN3136414

Détails

MKNK2 Protein (AA 1-465) (Strep Tag)

custom-made MKNK2 Origine: Humain Hôte: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, WB, SDS

N° du produit ABIN3093826