MKNK2 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

N° du produit ABIN2726084

Détail du produit

Antigène: MKNK2 (MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 2

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette MKNK2 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human MKNK2 (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: MKNK2 (MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))

Autre désignation: Mknk2 (MKNK2 Produits)

Synonymes: GPRK7 Protein, MNK2 Protein, gprk7 Protein, mnk2 Protein, 2010016G11Rik Protein, Gprk7 Protein, Mnk2 Protein, mknk2 Protein, wu:fb37e05 Protein, wz5090 Protein, fi34c11 Protein, wu:fi34c11 Protein, wu:fi41e12 Protein, zgc:55587 Protein, MAP kinase interacting serine/threonine kinase 2 Protein, MAP kinase-interacting serine/threonine kinase 2 Protein, MAP kinase interacting serine/threonine kinase 2b Protein, MAP kinase interacting serine/threonine kinase 2 L homeolog Protein, MAP kinase interacting serine/threonine kinase 2a Protein, MKNK2 Protein, mknk2 Protein, Mknk2 Protein, mknk2b Protein, mknk2.L Protein, mknk2a Protein

Sujet: This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization.

Poids moléculaire: 51.7 kDa

NCBI Accession: NP_951009

Pathways: Signalisation MAPK