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MKNK2 Produits

(MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))

Catégories

This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011].

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Catégories MKNK2 en vedette

MKNK2 Anticorps

High quality antibodies with extensive validation data.

MKNK2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

MKNK2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, PLA
Validations
  • (7)
N° du produit ABIN516167
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IF
Validations
  • (5)
N° du produit ABIN516166
Quantité 100 μg
Fiche technique Fiche technique

Application WB, IHC (p), IHC
Validations
  • (3)
N° du produit ABIN6744440
Quantité 100 μL
Fiche technique Fiche technique

MKNK2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6219467
Quantité 96 tests
Fiche technique Fiche technique

MKNK2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1310980
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1310978
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
N° du produit ABIN5509021
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits MKNK2

Scheper, Parra, Wilson, Van Kollenburg, Vertegaal, Han, Proud: "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization." dans: Molecular and cellular biology, Vol. 23, Issue 16, pp. 5692-705, (2003) (PubMed).

Scheper, Morrice, Kleijn, Proud: "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells." dans: Molecular and cellular biology, Vol. 21, Issue 3, pp. 743-54, (2001) (PubMed).

Knauf, Tschopp, Gram: "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2." dans: Molecular and cellular biology, Vol. 21, Issue 16, pp. 5500-11, (2001) (PubMed).

Synonymes et noms alternatifs relatifs à MKNK2

MAP kinase interacting serine/threonine kinase 2 (MKNK2), MAP kinase interacting serine/threonine kinase 2 (mknk2), MAP kinase-interacting serine/threonine kinase 2 (Mknk2), MAP kinase interacting serine/threonine kinase 2b (mknk2b), MAP kinase interacting serine/threonine kinase 2 L homeolog (mknk2.L), MAP kinase interacting serine/threonine kinase 2 (Mknk2), MAP kinase interacting serine/threonine kinase 2a (mknk2a), 2010016G11Rik, fi34c11, GPRK7, gprk7, Gprk7, mknk2, MNK2, mnk2, Mnk2, wu:fb37e05, wu:fi34c11, wu:fi41e12, wz5090, zgc:55587

Protein level used designations for MKNK2

  • G protein-coupled receptor kinase 7
  • MAP kinase signal-integrating kinase 2
  • MAP kinase-interacting serine/threonine-protein kinase 2
  • MAPK signal-integrating kinase 2
  • MAP kinase interacting serine/threonine kinase 2
  • MAP kinase-interacting serine/threonine kinase 2
  • mnk2
  • MAP kinase interacting serine/threonine kinase 2a
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