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NFASC Produits

(Neurofascin (NFASC))
This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009].

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Catégories NFASC en vedette

NFASC Anticorps

High quality antibodies with extensive validation data.

NFASC Kits ELISA

Reliable ELISA kits for a wide range of species.

NFASC Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

NFASC recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, IF (p), IF (cc), ICC, IHC (fro), IHC (p)
Validations
  • (4)
N° du produit ABIN727325
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB
Validations
  • (3)
N° du produit ABIN3017267
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (2)
N° du produit ABIN7191635
Quantité 100 μL
Fiche technique Fiche technique

NFASC recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6958098
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN2748418
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method
Validations
N° du produit ABIN1144672
Quantité 96 tests
Fiche technique Fiche technique

NFASC recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
N° du produit ABIN7197149
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1312436
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN3084479
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits NFASC

Arrambide, Espejo, Eixarch, Villar, Alvarez-Cermeño, Picón, Kuhle, Disanto, Kappos, Sastre-Garriga, Pareto, Simon, Comabella, Río, Nos, Tur, Castilló, Vidal-Jordana, Galán, Arévalo, Auger, Rovira et al.: "Neurofilament light chain level is a weak risk factor for the development of MS. ..." dans: Neurology, Vol. 87, Issue 11, pp. 1076-84, (2016) (PubMed).

OGuin, Gruber, Raine, Guzik, Poulos, Shafit-Zagardo: "Gas6 enhances axonal ensheathment by MBP+ membranous processes in human DRG/OL promyelinating co-cultures." dans: ASN neuro, Vol. 6, Issue 1, pp. e00135, (2014) (PubMed).

Jones, Korobova, Svitkina: "Axon initial segment cytoskeleton comprises a multiprotein submembranous coat containing sparse actin filaments." dans: The Journal of cell biology, Vol. 205, Issue 1, pp. 67-81, (2014) (PubMed).

Buffington, Sobotzik, Schultz, Rasband: "I?B? is not required for axon initial segment assembly." dans: Molecular and cellular neurosciences, Vol. 50, Issue 1, pp. 1-9, (2012) (PubMed).

Dhaunchak, Becker, Schulman, De Faria, Rajasekharan, Banwell, Colman, Bar-Or: "Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis." dans: Annals of neurology, Vol. 71, Issue 5, pp. 601-13, (2012) (PubMed).

Galiano, Jha, Ho, Zhang, Ogawa, Chang, Stankewich, Mohler, Rasband: "A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly." dans: Cell, Vol. 149, Issue 5, pp. 1125-39, (2012) (PubMed).

Yap, Vakulenko, Kruczek, Motamedi, Digilio, Liu, Winckler: "Doublecortin (DCX) mediates endocytosis of neurofascin independently of microtubule binding." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 22, pp. 7439-53, (2012) (PubMed).

Cortes, Landis, Ottens: "High-capacity peptide-centric platform to decode the proteomic response to brain injury." dans: Electrophoresis, Vol. 33, Issue 24, pp. 3712-9, (2012) (PubMed).

Shi, Sun, McBride, Cheng, Shi: "Acrolein induces myelin damage in mammalian spinal cord." dans: Journal of neurochemistry, Vol. 117, Issue 3, pp. 554-64, (2011) (PubMed).

Roza, Castillejo, Lopez-García: "Accumulation of Kv7.2 channels in putative ectopic transduction zones of mice nerve-end neuromas." dans: Molecular pain, Vol. 7, pp. 58, (2011) (PubMed).

Synonymes et noms alternatifs relatifs à NFASC

neurofascin (NFASC), neurofascin homolog (chicken) a (nfasca), neurofascin (Nfasc), AA387016, D430023G06Rik, mKIAA0756, NF, NRCAML, sc:d0205

Protein level used designations for NFASC

  • neurofascin
  • neurofascin homolog
  • neurofascin homolog (chicken)
  • neurofascin-like
  • neurofascin homolog (chicken) isoform 1
  • neurofascin homolog (chicken) isoform 2
  • neurofascin homolog (chicken) isoform 3
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