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NOXA Produits

(Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))

Catégories

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.

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Catégories NOXA en vedette

NOXA Anticorps

High quality antibodies with extensive validation data.

NOXA Kits ELISA

Reliable ELISA kits for a wide range of species.

NOXA Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

NOXA recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IF
Validations
  • (5)
N° du produit ABIN6145810
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, FACS
Validations
  • (4)
N° du produit ABIN7193484
Quantité 0.1 mg
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IF, IHC
Validations
  • (3)
N° du produit ABIN7163088
Quantité 100 μg
Fiche technique Fiche technique

NOXA recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6969250
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6969249
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Dog
Analytical Method
Validations
N° du produit ABIN1147675
Quantité 96 tests
Fiche technique Fiche technique

NOXA recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1315507
Quantité 25 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN3089046
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3130350
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits NOXA

Yang, Liu, Li, Chen, Zhao, Wei, Qiu, Liu, Zhou, Han, Wu, Ding: "Genome-scale CRISPR screening for potential targets of ginsenoside compound K." dans: Cell death & disease, Vol. 11, Issue 1, pp. 39, (2021) (PubMed).

Gallagher, Gunatilake, Beaumont, Sharp, Tiffen, Heinemann, Weninger, Haass, Wilmott, Madore, Ferguson, Rizos, Hersey: "HDAC inhibitors restore BRAF-inhibitor sensitivity by altering PI3K and survival signalling in a subset of melanoma." dans: International journal of cancer, Vol. 142, Issue 9, pp. 1926-1937, (2019) (PubMed).

Pilling, Hwang: "Targeting prosurvival BCL2 signaling through Akt blockade sensitizes castration-resistant prostate cancer cells to enzalutamide." dans: The Prostate, Vol. 79, Issue 11, pp. 1347-1359, (2019) (PubMed).

Minieri, De Dominici, Porazzi, Mariani, Spinelli, Rambaldi, Peterson, Porcu, Nevalainen, Calabretta: "Targeting STAT5 or STAT5-Regulated Pathways Suppresses Leukemogenesis of Ph+ Acute Lymphoblastic Leukemia." dans: Cancer research, Vol. 78, Issue 20, pp. 5793-5807, (2018) (PubMed).

Gonzalez, OPrey, Cardaci, Barthet, Sakamaki, Beaumatin, Roseweir, Gay, Mackay, Malviya, Kania, Ritchie, Baudot, Zunino, Mrowinska, Nixon, Ennis, Hoyle, Millan, McNeish, Sansom, Edwards, Ryan: "Mannose impairs tumour growth and enhances chemotherapy." dans: Nature, Vol. 563, Issue 7733, pp. 719-723, (2018) (PubMed).

Antignani, Segal, Simon, Kreitman, Huang, FitzGerald: "Essential role for Bim in mediating the apoptotic and antitumor activities of immunotoxins." dans: Oncogene, Vol. 36, Issue 35, pp. 4953-4962, (2017) (PubMed).

Ichikawa, Alves, Pfeiffer, Langa, Hernández-Santana, Suzuki, Prehn, Engel, Henshall: "Deletion of the BH3-only protein Noxa alters electrographic seizures but does not protect against hippocampal damage after status epilepticus in mice." dans: Cell death & disease, Vol. 8, Issue 1, pp. e2556, (2017) (PubMed).

Zhang, Huang, ONeill, Pang, Luo: "Bax/Bak activation in the absence of Bid, Bim, Puma, and p53." dans: Cell death & disease, Vol. 7, pp. e2266, (2016) (PubMed).

Long, Schoonen, Graczyk, OPrey, Ryan: "p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death." dans: Oncogene, (2015) (PubMed).

Wei, Noto, Zaika, Romero-Gallo, Piazuelo, Schneider, El-Rifai, Correa, Peek, Zaika: "Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner." dans: Gut, Vol. 64, Issue 7, pp. 1040-8, (2015) (PubMed).

Synonymes et noms alternatifs relatifs à NOXA

phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1), phorbol-12-myristate-13-acetate-induced protein 1 (pmaip1), phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1), APR, NOXA, Noxa, PMAIP1, TN3, zgc:162379

Protein level used designations for NOXA

  • phorbol-12-myristate-13-acetate-induced protein 1
  • Noxa
  • PMA-induced protein 1
  • adult T cell leukemia-derived PMA-responsive
  • immediate-early-response protein APR
  • protein Noxa
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