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ORAI1 Produits

(ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Catégories

The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011].

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Catégories ORAI1 en vedette

ORAI1 Anticorps

High quality antibodies with extensive validation data.

ORAI1 Kits ELISA

Reliable ELISA kits for a wide range of species.

ORAI1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse, Rat
Application WB, IHC, IF, FACS, LCI, ICC
Validations
  • (6)
N° du produit ABIN7043408
Quantité 25 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, IHC (p)
Validations
  • (3)
  • (2)
N° du produit ABIN541622
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
N° du produit ABIN7146306
Quantité 100 μg
Fiche technique Fiche technique

ORAI1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Analytical Method
Validations
N° du produit ABIN1124741
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method
Validations
N° du produit ABIN1124740
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method
Validations
N° du produit ABIN1124739
Quantité 96 tests
Fiche technique Fiche technique

ORAI1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3125369
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3117264
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits ORAI1

Domínguez-Rodríguez, Mayoral-Gonzalez, Avila-Medina, de Rojas-de Pedro, Calderón-Sánchez, Díaz, Hmadcha, Castellano, Rosado, Benitah, Gomez, Ordoñez, Smani: "Urocortin-2 Prevents Dysregulation of Ca2+ Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion." dans: Frontiers in physiology, Vol. 9, pp. 813, (2018) (PubMed).

Ávila-Medina, Calderón-Sánchez, González-Rodríguez, Monje-Quiroga, Rosado, Castellano, Ordóñez, Smani: "Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells." dans: The Journal of biological chemistry, Vol. 291, Issue 40, pp. 21148-21159, (2016) (PubMed).

Samanta, Kar, Mirams, Parekh: "Ca(2+) Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca(2+)-Dependent Nuclear Gene Expression." dans: Cell reports, Vol. 12, Issue 2, pp. 203-16, (2015) (PubMed).

Lee, Veatch, Baird, Holowka: "Molecular mechanisms of spontaneous and directed mast cell motility." dans: Journal of leukocyte biology, Vol. 92, Issue 5, pp. 1029-41, (2012) (PubMed).

Kar, Nelson, Parekh: "Selective activation of the transcription factor NFAT1 by calcium microdomains near Ca2+ release-activated Ca2+ (CRAC) channels." dans: The Journal of biological chemistry, Vol. 286, Issue 17, pp. 14795-803, (2011) (PubMed).

Krapivinsky, Krapivinsky, Stotz, Manasian, Clapham: "POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 48, pp. 19234-9, (2011) (PubMed).

Burns, Schmidt, Williams, Kim, Girirajan, Elsea: "Rai1 haploinsufficiency causes reduced Bdnf expression resulting in hyperphagia, obesity and altered fat distribution in mice and humans with no evidence of metabolic syndrome." dans: Human molecular genetics, Vol. 19, Issue 20, pp. 4026-42, (2010) (PubMed).

Martin, Willoughby, Ciruela, Ayling, Pagano, Wachten, Tengholm, Cooper: "Capacitative Ca2+ entry via Orai1 and stromal interacting molecule 1 (STIM1) regulates adenylyl cyclase type 8." dans: Molecular pharmacology, Vol. 75, Issue 4, pp. 830-42, (2009) (PubMed).

Smyth, Petranka, Boyles, DeHaven, Fukushima, Johnson, Williams, Putney: "Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis." dans: Nature cell biology, Vol. 11, Issue 12, pp. 1465-72, (2009) (PubMed).

Potier, Gonzalez, Motiani, Abdullaev, Bisaillon, Singer, Trebak: "Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 23, Issue 8, pp. 2425-37, (2009) (PubMed).

Synonymes et noms alternatifs relatifs à ORAI1

ORAI calcium release-activated calcium modulator 1 (ORAI1), ORAI calcium release-activated calcium modulator 1 (Orai1), ORAI calcium release-activated calcium modulator 1b (orai1b), ORAI calcium release-activated calcium modulator 1 S homeolog (orai1.S), ORAI calcium release-activated calcium modulator 1 (orai1), CRACM1, D730049H07Rik, im:7146264, LOC100218031, orai-1, orai1, ORAI1, orai2, ORAT1, RGD1311873, TMEM142A, Tmem142a, tmem142a, zgc:109721

Protein level used designations for ORAI1

  • calcium release-activated calcium channel protein 1
  • calcium release-activated calcium modulator 1
  • protein orai-1
  • transmembrane protein 142A
  • calcium release-activated calcium channel 1
  • ORAI calcium release-activated calcium modulator 1
  • protein orai-2
  • transmembrane protein 142B
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