ORC1 Produits
(Origin Recognition Complex, Subunit 1 (ORC1L))
Catégories
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
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Catégories ORC1 en vedette
ORC1 Anticorps
High quality antibodies with extensive validation data.
ORC1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
ORC1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
N° du produit
ABIN7187670
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
ELISA, IHC
Validations
- (2)
N° du produit
ABIN7252684
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC (p)
Validations
- (2)
N° du produit
ABIN518535
Quantité
100 μg
Fiche technique
Fiche technique
ORC1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1313648
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
N° du produit
ABIN3094294
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
N° du produit
ABIN3137604
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits ORC1
: "SCF(Fbxw15) mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation." dans: The Journal of biological chemistry, Vol. 288, Issue 9, pp. 6306-16, (2013) (PubMed).: "The cyclin A centrosomal localization sequence recruits MCM5 and Orc1 to regulate centrosome reduplication." dans: Journal of cell science, Vol. 123, Issue Pt 16, pp. 2743-9, (2010) (PubMed).
: "Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1." dans: The Journal of biological chemistry, Vol. 276, Issue 18, pp. 15397-408, (2001) (PubMed).
: "Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus." dans: The EMBO journal, Vol. 20, Issue 16, pp. 4588-602, (2001) (PubMed).
Synonymes et noms alternatifs relatifs à ORC1
Origin recognition complex subunit 1 (Orc1), origin recognition complex subunit 1 (Orc1), origin recognition complex subunit 1 (ORC1), origin recognition complex subunit 1 L homeolog (orc1.L), origin recognition complex, subunit 1 (Orc1), AA545195, CG10667, Dmel\\CG10667, DmORC1, DmOrc1, DmOrc1p, dORC1, HSORC1, MmORC1, ORC, ORC1, orc1, ORC1L, orc1l, Orc1l, PARC1, rDmORC, xorc1Protein level used designations for ORC1
- CG10667-PA
- Orc1-PA
- origin recognition complex 1
- origin recognition complex subunit 1
- origin recognition complex, subunit 1 homolog
- replication control protein 1
- origin recognition complex protein 1
- origin recognition complex, subunit 1-like
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