P5CS Produits
(Aldehyde Dehydrogenase 18 Family, Member A1 (ALDH18A1))
Catégories
This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene. [provided by RefSeq, Jul 2008].
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Catégories P5CS en vedette
P5CS Anticorps
High quality antibodies with extensive validation data.
P5CS Kits ELISA
Reliable ELISA kits for a wide range of species.
P5CS Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
P5CS recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (3)
N° du produit
ABIN519568
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (3)
N° du produit
ABIN652885
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
N° du produit
ABIN562547
Quantité
50 μL
Fiche technique
Fiche technique
P5CS recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
N° du produit
ABIN770580
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Pig
Analytical Method
Quantitative
Validations
N° du produit
ABIN778158
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rabbit
Analytical Method
Quantitative Competition ELISA
Validations
N° du produit
ABIN774259
Quantité
96 tests
Fiche technique
Fiche technique
P5CS recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7121771
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1344810
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1344809
Quantité
25 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits P5CS
: "Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway." dans: Molecular cancer research : MCR, Vol. 13, Issue 10, pp. 1408-20, (2016) (PubMed).: "Severe congenital cutis laxa with cardiovascular manifestations due to homozygous deletions in ALDH18A1." dans: Molecular genetics and metabolism, Vol. 112, Issue 4, pp. 310-6, (2014) (PubMed).
: "Nuclear cytoplasmic trafficking of proteins is a major response of human fibroblasts to oxidative stress." dans: Journal of proteome research, Vol. 13, Issue 10, pp. 4398-423, (2014) (PubMed).
: "Functional specialization in proline biosynthesis of melanoma." dans: PLoS ONE, Vol. 7, Issue 9, pp. e45190, (2012) (PubMed).
: "Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy." dans: Journal of proteomics, Vol. 75, Issue 7, pp. 2236-51, (2012) (PubMed).
: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." dans: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, (2010) (PubMed).
: "Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 24, Issue 2, pp. 474-485 (PubMed).
Synonymes et noms alternatifs relatifs à P5CS
aldehyde dehydrogenase 18 family member A1 (ALDH18A1), aldehyde dehydrogenase 18 family member A1 (aldh18a1), aldehyde dehydrogenase 18 family, member A1 (ALDH18A1), aldehyde dehydrogenase 18 family, member A1 (Aldh18a1), aldehyde dehydrogenase 18 family, member A1 (aldh18a1), aldehyde dehydrogenase 18 family member A1 L homeolog (aldh18a1.L), aldehyde dehydrogenase 18 family member A1 (Aldh18a1), 2810433K04Rik, AI429789, ALDH18A1, ARCL3A, cb842, cb899, GSAS, P5CS, PYCS, Pycs, pycs, sb:cb881, wu:fa91f10, wu:fi05f11, wu:fi17d12Protein level used designations for P5CS
- pyrroline-5-carboxylate synthetase
- aldehyde dehydrogenase 18 family, member A1
- Delta-1-pyrroline-5-carboxylate synthetase
- P5CS
- aldehyde dehydrogenase 18A1
- aldehyde dehydrogenase family 18 member A1
- delta-1-pyrroline-5-carboxylate synthase
- aldehyde dehydrogenase 18A1-like
- delta-1-pyrroline-5-carboxylate synthetase
- delta1-pyrroline-5-carboxlate synthetase
- pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase)
- glutamate gamma-semialdehyde synthetase
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