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PIK3C2A Produits

(Phosphoinositide-3-Kinase, Class 2, alpha Polypeptide (PIK3C2A))
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008].

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Catégories PIK3C2A en vedette

PIK3C2A Anticorps

High quality antibodies with extensive validation data.

PIK3C2A Kits ELISA

Reliable ELISA kits for a wide range of species.

PIK3C2A Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PIK3C2A recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (4)
N° du produit ABIN7431707
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC (p), IF
Validations
  • (4)
N° du produit ABIN518885
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application IHC, ELISA
Validations
  • (3)
N° du produit ABIN185194
Quantité 100 μg
Fiche technique Fiche technique

PIK3C2A recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6958551
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
N° du produit ABIN1116456
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN2851450
Quantité 96 tests
Fiche technique Fiche technique

PIK3C2A recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1315063
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
N° du produit ABIN5509086
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7410745
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits PIK3C2A

Gulluni, Martini, De Santis, Campa, Ghigo, Margaria, Ciraolo, Franco, Ala, Annaratone, Disalvatore, Bertalot, Viale, Noatynska, Compagno, Sigismund, Montemurro, Thelen, Fan, Meraldi, Marchiò, Pece et al.: "Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function. ..." dans: Cancer cell, Vol. 32, Issue 4, pp. 444-459.e7, (2017) (PubMed).

Mathew, Skuli, Mucaj, Lee, Zinn, Sathyan, Imtiyaz, Zhang, Davuluri, Rao, Venneti, Lal, Lathia, Rich, Keith, Minn, Simon: "miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 1, pp. 291-6, (2014) (PubMed).

Li, Smith: "PI3K/AKT pathway mediates induction of IL-1RA by TSH in fibrocytes: modulation by PTEN." dans: The Journal of clinical endocrinology and metabolism, Vol. 99, Issue 9, pp. 3363-72, (2014) (PubMed).

Arbuckle, Komiyama, Delaney, Coba, Garry, Rosie, Allchorne, Forsyth, Bence, Carlisle, ODell, Mitchell, Fleetwood-Walker, Grant: "The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment." dans: EMBO reports, Vol. 11, Issue 6, pp. 473-8, (2010) (PubMed).

Paulhe, Perret, Chap, Iberg, Morand, Racaud-Sultan: "Phosphoinositide 3-kinase C2alpha is activated upon smooth muscle cell migration and regulated by alpha(v)beta(3) integrin engagement." dans: Biochemical and biophysical research communications, Vol. 297, Issue 2, pp. 261-6, (2002) (PubMed).

Domin, Gaidarov, Smith, Keen, Waterfield: "The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles." dans: The Journal of biological chemistry, Vol. 275, Issue 16, pp. 11943-50, (2000) (PubMed).

Molz, Chen, Hirano, Williams: "Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain." dans: The Journal of biological chemistry, Vol. 271, Issue 23, pp. 13892-9, (1996) (PubMed).

Synonymes et noms alternatifs relatifs à PIK3C2A

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha (PIK3C2A), phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha (Pik3c2a), phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha (pik3c2a), phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha S homeolog (pik3c2a.S), phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (LOC100548137), phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha (Pik3c2a), phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha (pik3c2a), CPK, cpk, Cpk-m, PI3-K-C2(ALPHA), PI3-K-C2A, pi3-k-c2a, PI3KC2, sb:cb156, si:dkey-24l11.7, wu:fc02a04

Protein level used designations for PIK3C2A

  • C2-containing phosphatidylinositol kinase
  • PI3K-C2-alpha
  • PI3K-C2alpha
  • phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
  • phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha
  • phosphoinositide 3-kinase-C2-alpha
  • phosphoinositide-3-kinase, class 2, alpha polypeptide
  • ptdIns-3-kinase C2 subunit alpha
  • phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
  • phosphoinositide-3-kinase, class 2 alpha polypeptide
  • pi3-k-c2(alpha)
  • Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide
  • p170
  • LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
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