IL-4 Protéine

N° du produit ABIN1589638

Protéine Recombinant IL-4 exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour IL-4 Protéine (ABIN1589638)

Antigène: IL-4 (IL4) (Interleukin 4 (IL4))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 98 % by SDS-PAGE

Détail du produit

Fonction: IL-4

Séquence: MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS

Specificité: Chromosomal location:5q31.1

Attributs du produit: Length (aa):130

niveau d'endotoxine: < 0.1 ng per μg of IL-4

Information d'application

Indications d'application: The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is 0.1-0.5 ng/mL.

Commentaires:

Cytokines & Growth Factors

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: The lyophilized IL-4 should be reconstituted in water to a concentration not less than 100 μg/mL. This solution can be diluted into other buffered solutions or stored at -20 °C for future use.

Buffer: PBS

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: RT,0 °C,4 °C,-20 °C

Stockage commentaire: The lyophilized IL-4, though stable at room temperature, is best stored desiccated below 0°C. Reconstituted IL-4 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.

Détail du antigène

Antigène: IL-4 (IL4) (Interleukin 4 (IL4))

Autre désignation: IL-4

Sujet: IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 14.9 kDa globular protein containing 130 amino acid residues
Synonyms: IL4, BSF1, IL-4, BCGF1, BSF-1, BCGF-1

Poids moléculaire: 14.9 kDa

ID gène: 3565

NCBI Accession: NM_000589, NP_000580

UniProt: P05112

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation