Leptin Receptor Protein (LEPR) (C-Term, Extracellular Domain)

N° du produit ABIN1684639

Cette protéine Recombinant Leptin Receptor est produite dans HEK-293T Cells.

Aperçu rapide pour Leptin Receptor Protein (LEPR) (C-Term, Extracellular Domain) (ABIN1684639)

Antigène: Leptin Receptor (LEPR)

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293T Cells

Pureté: > 98 %, as determined by SDS-PAGE and HPLC

Détail du produit

Attributs du protein: C-Term, Extracellular Domain

Specificité: Optimized DNA sequence encoding extracellular domain of human leptin receptor including a C-terminal Human IgG1 Fc tag was expressed in HEK293 cells.

Attributs du produit: Recombinant human leptin receptor is a homodimer protein consisting of two 1070 amino acid residue subunit chains, due to glycosylation migrates as an approximately 160kDa protein on SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Information d'application

Commentaires:

Biologically active: Measured by its ability to bind immobilized recombinant human Leptin (1 µg/mL) at a linear concentration range of 0.01-4 µg/mL.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS solution, pH7.2

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: The lyophilized antibody is stable for at least 1 year from date of receipt at -20 °C. Upon reconstitution, this antibody can be stored in working aliquots at - 8 °C for one month, or at -20 °C for six months without detectable loss of activity.

Date de péremption: 12 months

Détail du antigène

Antigène: Leptin Receptor (LEPR)

Autre désignation: LEPR

Sujet: FGF-10 is involved in the initial budding as well as the continuous outgrowth of vertebrate limbs, FGF10 mRNA is expressed preferentially in neurons but not in glial cells and may have a distinct role in the brain. Human FGF-10 is mitogenic for fetal rat keratinizing epidermal cells but not for NIH 3T3 cells. Recombinant FGF-10 induces the proliferation of human urothelial cells in vitro and induces the proliferation of transitional epithelium. FGF-10 is secreted by cultured mouse pre-adipocytes, prevention of FGF-10 signaling inhibits subsequent differentiation. The ability of embryonic fibroblasts derived from FGF-10 knock-out mice to differentiate into adipocytes is also impaired.

UniProt: P48357

Pathways: Signalistation JAK/STAT, AMPK Signaling, Feeding Behaviour