SNCA Protein (AA 1-140) (Biotin)

N° du produit ABIN1882765

Protéine Recombinant SNCA exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour SNCA Protein (AA 1-140) (Biotin) (ABIN1882765)

Antigène: SNCA (Synuclein, alpha (SNCA))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Détail du produit

Attributs du protein: AA 1-140

Purification/Conjugué: Cette SNCA protéine est marqué à la Biotin.

Attributs du produit: Recombinant human alpha-synuclein (1-140) was expressed and purified from E. coli and conjugated with biotin.

Purification: Purified from E. Coli.

Information d'application

Restrictions: For Research Use only

Stockage

Stock: -80 °C

Détail du antigène

Antigène: SNCA (Synuclein, alpha (SNCA))

Autre désignation: alpha-Synuclein

Sujet: Parkinson's disease is predominantly a movement disorder resulting from degeneration of dopaminergic neurons in the substantia nigra. The cause of the disease is unknown, but substantial evidence suggests that the aggregation of alpha-synuclein is a critical step in the etiology of Parkinson's disease (PD). alpha-Synuclein is an abundant brain protein of 140 residues that is present in high concentration at presynaptic terminals and is found in both soluble and membrane-associated fractions of the brain. Several possible functions have been suggested for alpha-synuclein, and it also appears to be involved in vesicle release and trafficking. In vitro incubation in the presence of a specific amount of salt (i.e. 0.1 M NaCl) with agitation shows alpha-synuclein forming fibrilous structure.

NCBI Accession: NP_000336

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity