SNCA Protein (AA 1-140) (HiLyte Fluor 488)
Aperçu rapide pour SNCA Protein (AA 1-140) (HiLyte Fluor 488) (ABIN1882766)
Antigène
Voir toutes SNCA ProtéinesType de proteíne
Origine
Source
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Attributs du protein
- AA 1-140
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Purification/Conjugué
- Cette SNCA protéine est marqué à la HiLyte Fluor 488.
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Attributs du produit
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The recombinant human alpha-synuclein (1-140) was expressed and purified from E. coli and conjugated with the fluorescence dye HiLyte FluorTM 488.
Green fluorescence.
Excitation/Emission wavelengths= 503 nm/525 nm -
Purification
- Purified from E. Coli.
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Restrictions
- For Research Use only
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Conseil sur la manipulation
- Protect from light!
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Stock
- -80 °C
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- SNCA (Synuclein, alpha (SNCA))
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Autre désignation
- alpha-Synuclein
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Sujet
- Parkinson's disease (PD) is predominantly a movement disorder resulting from degeneration of dopaminergic neurons in the substantia nigra. The cause of the disease is unknown, but substantial evidence suggests that the aggregation of alpha-synuclein is a critical step in the etiology of PD. alpha-Synuclein is an abundant protein of 140 residues that is present in high concentration at presynaptic terminals and is found in both soluble and membrane-associated fractions of the brain. Several possible functions have been suggested, among which are vesicle release and trafficking. In vitro incubation in the presence of salt (i.e. 0.1 M NaCl) with agitation causes alpha-synuclein to form fibrils.
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NCBI Accession
- NP_000336
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Pathways
- Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
Antigène
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