GDNF Protein (AA 77-211)

N° du produit ABIN2017883

Cette protéine Recombinant GDNF est produite dans CHO Cells.

Aperçu rapide pour GDNF Protein (AA 77-211) (ABIN2017883)

Antigène: GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: CHO Cells

Pureté: > 95 % as analyzed by SDS-PAGE and HPLC.

Détail du produit

Attributs du protein: AA 77-211

Attributs du produit: ED50 <8 μg /mL, measured in a bioassay using C6 cells.

niveau d'endotoxine: < 0.2 EU/μg, determined by LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Stock: -80 °C

Stockage commentaire: Lyophilized recombinant murine GDNF remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Murine GDNF should be stable up to 1 week at 4°C or up to 2 months at -20°C.

Date de péremption: 6 months

Détail du antigène

Antigène: GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))

Sujet: Glial-Derived Neurotrophic Factor, also known as GDNF and ATF-1, is a neurotrophic factor belonging to the TGF-beta family. It is expressed in both central nervous system (CNS) and non-CNS tissues. GDNF signals through a receptor system composed of a RET and one of the four GFR alpha receptors. It promotes the survival and differentiation of dopaminergic neurons, and increases their high-affinity dopamine uptake. In a mouse Parkinson's Disease model, GDNF has been shown to improve bradykinesia, rigidity, and postural instability. GDNF has also been shown to regulate kidney development, spermatogenesis and affect alcohol consumption.
Synonyms: Glial-Derived Neurotrophic Factor, ATF-1

Poids moléculaire: 17-22 kDa, observed by reducing SDS-PAGE.

UniProt: P48540

Pathways: Signalisation RTK, Synaptic Membrane, Tube Formation, Autophagy, Smooth Muscle Cell Migration