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IL-3 Protein (AA 33-166)

IL-3 Origine: Souris Hôte: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE analysis. Active
N° du produit ABIN2018102
  • Antigène Voir toutes IL-3 Protéines
    IL-3 (Interleukin 3 (IL-3))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 33-166
    Origine
    • 26
    • 13
    • 7
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Souris
    Source
    • 30
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Attributs du produit
    ED50 < 0.05 ng/mL, measured by a cell proliferation assay using M-NFS-60 cells, corresponding to a specific activity of > 2 x 10^7 units/mg.
    AA 33-166, expressed with an N-terminal Met.
    Pureté
    > 95 % by SDS-PAGE analysis.
    niveau d'endotoxine
    < 0.2 EU/μg, determined by LAL method.
    Top Product
    Discover our top product IL-3 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstituted in ddH2O at 100 μg/mL.
    Buffer
    Lyophilized after extensive dialysis against PBS.
    Stock
    -80 °C
    Stockage commentaire
    Lyophilized recombinant mouse Interleukin-3 (rmIL-3) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rmIL-3 remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
    Date de péremption
    6 months
  • Antigène
    IL-3 (Interleukin 3 (IL-3))
    Autre désignation
    Interleukin-3 (IL-3) (IL-3 Produits)
    Synonymes
    BPA Protein, Csfmu Protein, HCGF Protein, Il-3 Protein, MCGF Protein, PSF Protein, IL-3 Protein, MULTI-CSF Protein, interleukin 3 Protein, interleukin 3 (colony-stimulating factor, multiple) Protein, Il3 Protein, IL3 Protein
    Sujet
    Interleukin-3 (IL-3) is a pleiotropic cytokine belonging to the interleukin family. IL-3 shares similarities with Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and IL-5: they all have a four-helix bundle structure, are located on the same chromosomes in both human and mouse, are produced by activated T cells, and share receptors. The IL-3/IL-5/GM-CSF receptor family members are all heterodimeric, composed of a receptor-specific alpha chain and a common beta chain. IL-3 is also called multi-colony stimulating factor since it stimulates the development and colony formation of multiple lineages of hematopoietic cells by activating intracellular pathways such as Ras-Raf-ERK and JAK/STAT. IL-3 inhibits apoptosis and promotes cell survival by targeting the anti-apoptotic bcl-2 gene family. Recombinant mouse Interleukin-3 (rmIL-3) produced in E. coli is a single non-glycosylated polypeptide chain containing of 135 amino acids. A fully biologically active molecule, rmIL-3 has a molecular mass of 15.2 kDa analyzed by non-reducing SDS-PAGE.
    Synonyms: MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor
    Poids moléculaire
    15.2 kDa, observed by non-reducing SDS-PAGE.
    UniProt
    P01586
    Pathways
    Signalistation JAK/STAT, Regulation of Carbohydrate Metabolic Process, Autophagy
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