IL4 Receptor Protein (AA 24-232)

N° du produit ABIN2018122

Cette protéine Recombinant IL4 Receptor est produite dans HEK-293T Cells.

Aperçu rapide pour IL4 Receptor Protein (AA 24-232) (ABIN2018122)

Antigène: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293T Cells

Pureté: > 95 % as analyzed by SDS-PAGE and HPLC.

Détail du produit

Attributs du protein: AA 24-232

Attributs du produit: ED50 < 70 ng/mL, measured in a neutralization assay using TF-1 cells in the presence of 0.5 ng/mL h-IL-4.

niveau d'endotoxine: < 0.2 EU/μg, determined by LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Stock: -80 °C

Stockage commentaire: Lyophilized recombinant Human Interleukin-4 Receptor remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human Interleukin-4 Receptor should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Date de péremption: 6 months

Détail du antigène

Antigène: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Autre désignation: Interleukin-4 Receptor

Sujet: Interleukin-4 Receptor, also known as IL-4RA and CD124, is a transmembrane glycoprotein belonging to the class I receptor family. It is highly expressed by activated T-cells. IL-4RA couples with gamma chain to form the type I receptor for IL-4. The extracellular domain of IL-4RA binds to IL-4 and antagonizes its activity. IL-4RA plays an important role in Th2 cell differentiation, Ig class switching and alternative macrophage activation. It has also been implicated in allergic inflammation, tumor progression and atherogenesis.
Synonyms: IL-4R, IL-4RA, CD124

Poids moléculaire: 40-45 kDa, observed by reducing SDS-PAGE.

UniProt: P24394

Pathways: Signalistation JAK/STAT, Positive Regulation of Immune Effector Process