NOG Protein (AA 20-232)

N° du produit ABIN2018288

Cette protéine Recombinant NOG est produite dans CHO Cells. Il y a 1 publication disponible.

Aperçu rapide pour NOG Protein (AA 20-232) (ABIN2018288)

Antigène: NOG (Noggin (NOG))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: CHO Cells

Pureté: > 95 % as analyzed by SDS-PAGE.

Détail du produit

Attributs du protein: AA 20-232

Attributs du produit: ED50< 60 ng/mL, measured in a bioassay using ATDC5 cells in the presence of 10 ng/mL human BMP-4.

niveau d'endotoxine: < 0.2 EU/μg, determined by LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Stock: -80 °C

Stockage commentaire: Lyophilized recombinant murine Nogginremains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, murine Nogginshould be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Date de péremption: 6 months

Référence

Bohnenpoll, Wittern, Mamo, Weiss, Rudat, Kleppa, Schuster-Gossler, Wojahn, Lüdtke, Trowe, Kispert: "A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development." dans: PLoS genetics, Vol. 13, Issue 8, pp. e1006951, (2017) (PubMed).

Détail du antigène

Antigène: NOG (Noggin (NOG))

Autre désignation: Noggin

Sujet: Noggin, also known as NOG, is a homodimeric glycoprotein that binds to and modulates the activity of TGF-beta family ligands. It is expressed in condensing cartilage and immature chondrocytes. Noggin antagonizes bone morphogenetic protein (BMP) activities by blocking epitopes on BMPs needed for binding to their receptors.Noggin has been shown to be involved in many developmental processes, such as neural tube formation and joint formation. During development, Noggin diffuses through extracellular matrices and forms morphogenic gradients that regulate cellular responses in a concentration-dependent manner.
Synonyms: NOG

Poids moléculaire: 29-31 kDa, observed by reducing SDS-PAGE.

UniProt: P97466

Pathways: Stem Cell Maintenance, Tube Formation