Oncostatin M Protein (OSM) (AA 26-252)
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- Antigène Voir toutes Oncostatin M (OSM) Protéines
- Oncostatin M (OSM)
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 26-252
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Attributs du produit
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ED50 < 10 ng/mL, measured by a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 1x 10^5 units/mg.
AA 26-252, expressed with an N-terminal Met. - Pureté
- > 95 % by SDS-PAGE analysis.
- niveau d'endotoxine
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product OSM Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Stock
- -80 °C
- Stockage commentaire
- Lyophilized recombinant human Oncostatin M (rhOSM) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhOSM should be stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
- Date de péremption
- 6 months
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- Antigène
- Oncostatin M (OSM)
- Abstract
- OSM Produits
- Synonymes
- OSM Protein, OncoM Protein, oncostatin M Protein, OSM Protein, Osm Protein
- Sujet
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Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, including IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. In vivo, OSM is secreted from activated T cells, monocytes, neutrophils, and endothelial cells. OSM is related to LIF, and share a receptor with LIF in human. Human OSM can bind to gp130 and recruit OSM Receptor beta or LIF Receptor beta to form a ternary complex. OSM stimulates the growth of different types of cells, including megakaryocytes, fibroblasts, vascular endothelial cells, and T cells. On the other hand, OSM inhibits the proliferation of several cancer cell lines, such as solid tissue tumor cells, lung cancer cells, melanoma cells, and breast cancer cells.Recombinant human Oncostatin M (rhOSM) produced in E. coli is a single non-glycosylated polypeptide chain containing 228 amino acids. A fully biologically active molecule, rhOSM has a molecular mass of 25.9 kDa analyzed by reducing SDS-PAGE.
Synonyms: OSM - Poids moléculaire
- 25.9 kDa, observed by reducing SDS-PAGE.
- UniProt
- P13725
- Pathways
- Signalistation JAK/STAT, Negative Regulation of Hormone Secretion
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