CD86 Protein (CD86) (Fc Tag)

N° du produit ABIN2566448

Protéine Recombinant CD86 exprimée dans HEK-293 Cells.

Aperçu rapide pour CD86 Protein (CD86) (Fc Tag) (ABIN2566448)

Antigène: CD86

Type de proteíne: Recombinant

Origine: Cynomolgus, Macaque rhésus

Source: HEK-293 Cells

Application: Western Blotting (WB)

Pureté: 95 % as determined by SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette CD86 protéine est marqué à la Fc Tag.

Attributs du produit:

Fusion tag: C-Fc Tag

Information d'application

Indications d'application: This recombinant protein can be used for WB. For research use only.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM tris, 100 mM glycine, pH 7.5

Stock: -80 °C,-20 °C

Stockage commentaire: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Détail du antigène

Antigène: CD86

Autre désignation: CD86

Sujet: Cluster of Differentiation 86 (CD86) is also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B72 is expressed at low levels on monocytes and can be upregulated through interferon γ. CD86 is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. Recent study has revealed that B7-2 promotes the generation of a mature APC repertoire and promotes APC function and survival. Furthermore, the B7 proteins are also involved in innate immune responses by activating NF-κB-signaling pathway in macrophages. CD86 thus is regarded as a promising candidate for immune therapy. CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.

Poids moléculaire: 52 kDa

ID gène: 714390

UniProt: Q9BDM4

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation