Clusterin Protein (CLU) (His tag)

N° du produit ABIN2566468

Cette protéine Recombinant Clusterin est exprimée dans HEK-293 Cells.

Aperçu rapide pour Clusterin Protein (CLU) (His tag) (ABIN2566468)

Antigène: Clusterin (CLU)

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Application: Western Blotting (WB)

Pureté: >92 % as determined by SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette Clusterin protéine est marqué à la His tag.

Attributs du produit:

Measured by its ability to induce clustering of human clear cell carcinoma epithelial cells Caki-2. Measured by its ability to inhibit DTT (Dithiothreitol) induced BSA precipitation.

Information d'application

Indications d'application: This recombinant protein can be used for WB. For research use only.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -80 °C,-20 °C

Stockage commentaire: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Détail du antigène

Antigène: Clusterin (CLU)

Autre désignation: Clusterin

Sujet: Clusterin (CLU) is also known as dimeric acidic glycoprotein (DAG protein), testosterone repressed prostate message-2 (TRPM-2), sulfated glycoprotein-2 (SGP-2) and complement lysis inhibitor (CLI), is a secreted multifunctional glycoprotein protein which belongs to the clusterin family. Intracellular cleavages of the precursor of clusterin remove the signal peptide and generate comparably sized α and β chains which are secreted as an 80 kDa N-glycosylated disulfide-linked heterodimer. DAG protein is predominantly expressed in adult testis, ovary, adrenal gland, liver, heart, and brain and in many epithelial tissues during embryonic development. Clusterin involve in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.

Poids moléculaire: 50.9 kDa (Disulfide - linked heterodimer)

ID gène: 1191

NCBI Accession: NP_001822

UniProt: P10909

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling