Fibulin 5 Protein (FBLN5) (Myc-DYKDDDDK Tag)

N° du produit ABIN2721183

Cette protéine Recombinant Fibulin 5 est produite dans HEK-293 Cells. Il y a 1 publication disponible.

Aperçu rapide pour Fibulin 5 Protein (FBLN5) (Myc-DYKDDDDK Tag) (ABIN2721183)

Antigène: Fibulin 5 (FBLN5)

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Détail du produit

Purification/Conjugué: Cette Fibulin 5 protéine est marqué à la Myc-DYKDDDDK Tag.

Attributs du produit:

• Recombinant human Fibulin-5 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Référence

Sideek, Menz, Parsi, Gibson: "LTBP-2 competes with tropoelastin for binding to fibulin-5 and heparin, and is a negative modulator of elastinogenesis." dans: Matrix biology : journal of the International Society for Matrix Biology, Vol. 34, pp. 114-23, (2014) (PubMed).

Détail du antigène

Antigène: Fibulin 5 (FBLN5)

Autre désignation: Fibulin-5

Sujet: The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).

Poids moléculaire: 47.8 kDa

NCBI Accession: NP_006320

Pathways: SARS-CoV-2 Protein Interactome