FGF1 Protein (AA 16-155)

N° du produit ABIN2745666

Cette protéine Recombinant FGF1 est produite dans Escherichia coli (E. coli).

Aperçu rapide pour FGF1 Protein (AA 16-155) (ABIN2745666)

Antigène: FGF1 (Fibroblast Growth Factor 1 (Acidic) (FGF1))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Pureté: >95 % (SDS-PAGE)

Détail du produit

Attributs du protein: AA 16-155

Fonction: FGF-1 (human) (rec.) (untagged)

Réactivité croisée: Humain

Attributs du produit: Human FGF-1 (aa 16-155) is untagged.

niveau d'endotoxine: <0.01EU/μg purified protein (LAL test).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with 100 μL sterile water.

Concentration: 0.1 mg/mL

Buffer: In PBS containing 0.2 mM DTT.

Conseil sur la manipulation: After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.

Stock: 4 °C,-20 °C

Stockage commentaire:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Date de péremption: 6 months

Détail du antigène

Antigène: FGF1 (Fibroblast Growth Factor 1 (Acidic) (FGF1))

Autre désignation: FGF-1

Sujet:

Fibroblast Growth Factor 1, Acidic Fibroblast Growth Factor, Endothelial Cell Growth Factor, ECGF, Heparin-binding Growth Factor 1, HBGF-1

Fibroblast growth factors (FGFs) constitute a family of heparin-binding polypeptides involved in the regulation of biological responses such as growth, differentiation and angiogenesis. The biological effects of FGFs are mediated by four structurally related receptor tyrosine kinases denoted FGFR1, FGFR2, FGFR3 and FGFR4. FGF-1 [FGF-acidic, ECGF, HBGF-1] is a powerful mitogen of cells of mesodermal, ectodermal and endodermal origin. FGF-1 association with heparan sulfate is a prerequisite for activation of FGF receptors. FGF-1 plays a role in various stages of development and morphogenesis as well as in angiogenesis and wound healing processes. Recent data indicate a role of FGF-1 in inflammation and obesity. FGF-1 is selectively induced in fat cells by high-fat diet feeding and established the PPARgamma-FGF-1 axis as a critical pathway that regulates adipose tissue remodeling.

Poids moléculaire: ~16kDa

UniProt: P05230

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway