PLG Protéine
Aperçu rapide pour PLG Protéine (ABIN2830498)
Antigène
Voir toutes PLG ProtéinesType de proteíne
Activité biologique
Origine
Source
Application
Pureté
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Séquence
- VYLSECKTGN GKNYRGTMSK TKNGITCQKW SSTSPHRPRF SPATHPSEGL EENYCRNPDN DPQGPWCYTT DPEKRYDYCD ILECEEECMH CSGENYDGKI SKTMSGLECQ AWDSQSPHAH GYIPSKFPNK NLKKNYCRNP DRELRPWCFT TDPNKRWELC DIPRCTTPPP SSGPTYQCLK GTGENYRGNV AVTVSGHTCQ HWSAQTPHTH NRTPENFPCK NLDENYCRNP DGKRAPWCHT TNSQVRWEYC KIPSCDSSP
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Attributs du produit
- Biological Activity: Fully biologically active when compared to standard. The specific activity determined by an assay on anti-proliferation and anti-migration using endothelial cells in vitro and anti-angiogenesis in vivo is 5.5 x 105 IU/mg.
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Stérilité
- 0.2 μm filtered
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Plasminogen (PLG) (AA 98-356) protein (His-IF2DI Tag)
PLG Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Plasminogen (PLG) (AA 1-810) protein (GST tag)PLG Origine: Humain Hôte: Wheat germ Recombinant WB, ELISA, AP, AA
Plasminogen (PLG) (AA 100-352) protein (His tag)PLG Origine: Humain Hôte: Yeast (Pichia pastoris) Recombinant > 95 % WB, SDS, ELISA, IP
Plasminogen (PLG) (AA 79-466) protein (His tag)PLG Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 90 % WB, SDS, Imm, PC
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- 20 mM NaAc, pH 5.5, 4 % mannitol
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Stock
- -20 °C
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- PLG (Plasminogen (PLG))
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Autre désignation
- PLG
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Sujet
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Relevance: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. {ECO:0000269|PubMed:14699093}., Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. {ECO:0000269|PubMed:14699093}.
Synonyms: EC 3.4.21.7, -
Poids moléculaire
- 29.7 kDa
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UniProt
- P00747
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Pathways
- Système du Complément, Lipid Metabolism
Antigène
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