Angiopoietin 2 Protein (ANGPT2) (Fc Tag)

N° du produit ABIN7320897

Protéine Recombinant Angiopoietin 2 exprimée dans Human Cells.

Aperçu rapide pour Angiopoietin 2 Protein (ANGPT2) (Fc Tag) (ABIN7320897)

Antigène: Angiopoietin 2 (ANGPT2)

Type de proteíne: Recombinant

Origine: Souris

Source: Human Cells

Pureté: >95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette Angiopoietin 2 protéine est marqué à la Fc Tag.

Fonction: Recombinant Mouse Angiopoietin-2/ANG2 (C-Fc)

Séquence: Tyr19-Phe496

Attributs du produit: Recombinant Mouse Angiopoietin-2 is produced by our Mammalian expression system and the target gene encoding Tyr19-Phe496 is expressed with a Fc tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Angiopoietin 2 (ANGPT2)

Autre désignation: Angiopoietin-2/ANG2

Sujet:

Background: Angiopoietin-2 (Ang-2, also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Both Ang-2 and the related Angiopoietin-1 (Ang-1) are ligands for the receptor tyrosine kinase Tie-2. While Ang-1 is a potent Tie 2 agonist, Ang-2 may act as either a Tie-2 antagonist or agonist, depending upon its state of multimerization. The higher the order of oligomer, the more effective Ang-2 becomes as a Tie-2 agonist. The short isoform appears to block the binding of either Ang-1 or full-length Ang-2 to Tie-2. Ang-2 functions as a pro-angiogenic factor, although it can also induce EC death and vessel regression. Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. In addition, ANG-2 is strongly expressed in the vasculature of many tumors and it has been suggested that ANG-2 may act synergistically with other cytokines such as vascular endothelial growth factor to promote tumor-associated Angiogenesis and tumor progression.

Synonym: AGPT2, ANG2, ANG-2, angiopoietin 2, Angiopoietin-2, angiopoietin-2a, angiopoietin-2B, angiopoitin 2, ANGPT2, Tie2-ligand

Poids moléculaire: 81.4 kDa

UniProt: O35608

Pathways: Signalisation RTK