Angiopoietin 2 Protein (ANGPT2) (AA 19-496) (DYKDDDDK Tag)

N° du produit ABIN1344329

Détail du produit

Antigène: Angiopoietin 2 (ANGPT2)

Type de proteíne: Recombinant

Attributs du protein: AA 19-496

Origine: Humain, Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette Angiopoietin 2 protéine est marqué à la DYKDDDDK Tag.

Application: SDS-PAGE (SDS)

Specificité: Binds to the human and mouse Tie-2 receptor.

Réactivité croisée: Humain, Souris

Attributs du produit: Human angiopoietin-2 (aa 19-496) is fused at the N-terminus to a FLAG®-tag.

Pureté: >95 % (SDS-PAGE)

niveau d'endotoxine: <0.01EU/μg purified protein (LAL test, Lonza).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with 100 μL sterile water.

Concentration: Lot specific

Buffer: Lyophilized. Contains PBS with trehalose and Brij35.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Date de péremption: 6 months

Référence

Kim, Shin, Kim, Choi, Byun, Jeon, Suh, Kim: "Interaction between Tie receptors modulates angiogenic activity of angiopoietin2 in endothelial progenitor cells." dans: Cardiovascular research, Vol. 72, Issue 3, pp. 394-402, (2006) (PubMed).

Détail du antigène

Antigène: Angiopoietin 2 (ANGPT2)

Autre désignation: Angiopoietin-2 (ANGPT2 Produits)

Synonymes: AGPT2 Protein, ANG2 Protein, Agpt2 Protein, Ang-2 Protein, Ang2 Protein, ang2 Protein, angpt2 Protein, ANGIOPOIETIN-2 Protein, ANG-2 Protein, ANGPT2 Protein, Angrp Protein, Rnase5b Protein, ANG3 Protein, C11orf2 Protein, C11orf3 Protein, FFR Protein, angiopoietin 2 Protein, angiopoietin 2b Protein, angiogenin, ribonuclease A family, member 2 Protein, VPS51, GARP complex subunit Protein, ANGPT2 Protein, Angpt2 Protein, angpt2b Protein, Ang2 Protein, VPS51 Protein

Sujet: Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context.

Poids moléculaire: ~70kDa (SDS-PAGE)

UniProt: O15123

Pathways: Signalisation RTK