Betacellulin Protein (BTC) (His tag)

N° du produit ABIN7320473

Cette protéine Recombinant Betacellulin est exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour Betacellulin Protein (BTC) (His tag) (ABIN7320473)

Antigène: Betacellulin (BTC)

Type de proteíne: Recombinant

Origine: Souris

Source: Escherichia coli (E. coli)

Pureté: > 95 % as determined by SDS-PAGE

Détail du produit

Purification/Conjugué: Cette Betacellulin protéine est marqué à la His tag.

Fonction: Recombinant Mouse Betacellulin/BTC Protein (His Tag)

Séquence: Asp32-Gln118

Attributs du produit: Recombinant Mouse Betacellulin is produced by our E.coli expression system and the target gene encoding Asp32-Gln118 is expressed with a 6His tag at the N-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Betacellulin (BTC)

Autre désignation: Betacellulin/BTC

Sujet:

Background: Mouse Betacellulin is a single type I membrane protein which belongs to the EGF family of cytokines. EGF family has many members including EGF, TGF-a, Amphiregulin, HB-EGF, Epiregulin, Tomoregulin and the Neuregulins. Betacellulin is characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. Betacellulin is expressed in several tissues and tumor cells including kidney, uterus, liver, pancreas and small intestine. Betacellulin binds and activates ErbB-1 and ErbB-4 homodimers. Betacellulin is thought to play a role in the differentiation of pancreatic beta cells.Human and mouse mature BTC protein are 80 % identical at the amino acid sequence level. Betacellulin is involved in many biological processes such as stimulating gastrointestinal growth. It is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen for a wide variety of cell types.

Synonym: Btc,Betacellulin,Betacellulin, epidermal growth factor family member,Betacellulin, epidermal growth factor family member, isoform CRA_a,mCG_12529

Poids moléculaire: 12.2 kDa

UniProt: Q543J8

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway