BDNF Protein (AA 19-247)
Aperçu rapide pour BDNF Protein (AA 19-247) (ABIN7319494)
Antigène
Voir toutes BDNF ProtéinesType de proteíne
Origine
Source
Pureté
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Attributs du protein
- AA 19-247
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Fonction
- Recombinant Human BDNF Protein (with pro peptide)
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Séquence
- Ala19-Arg247(R125A,R127A,R128A)
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Attributs du produit
- Recombinant Human BDNF is produced by our E.coli expression system and the target gene encoding Ala19-Arg247 is expressed.
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Stérilité
- 0.2 μm filtered
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niveau d'endotoxine
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Brain-Derived Neurotrophic Factor (BDNF) (Active) protein (Biotin)
BDNF Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant WB, CC, in vivo, Diff, AD, CyTox, LCI, IF, FM Active
Brain-Derived Neurotrophic Factor (BDNF) (AA 1-255) protein (GST tag)BDNF Origine: Humain Hôte: Wheat germ Recombinant AP, AA, ELISA, WB
Brain-Derived Neurotrophic Factor (BDNF) (AA 1-247) protein (GST tag)BDNF Origine: Humain Hôte: Wheat germ Recombinant AP, AA, ELISA, WB
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM PB, 10 % Trehalose, 100 mM NaCl, 0.02 % Tween 80, pH 6.0.
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Stock
- -20 °C
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Stockage commentaire
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Date de péremption
- 6 months
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- BDNF (Brain-Derived Neurotrophic Factor (BDNF))
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Autre désignation
- BDNF
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Sujet
- Abrineurin,BDNF,Brain-Derived Neurotrophic Factor,The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
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Poids moléculaire
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Calculated MW: 25.6 kDa
Observed MW: 28 kDa
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ID gène
- 627
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UniProt
- P23560
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Pathways
- Signalisation RTK, Synaptic Membrane, Feeding Behaviour, Dicarboxylic Acid Transport, Regulation of long-term Neuronal Synaptic Plasticity
Antigène
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