CD80 Protein (CD80) (His tag)

N° du produit ABIN7321262

Cette protéine Recombinant CD80 est produite dans Human Cells.

Aperçu rapide pour CD80 Protein (CD80) (His tag) (ABIN7321262)

Antigène: CD80

Type de proteíne: Recombinant

Origine: Rat

Source: Human Cells

Pureté: > 95 % as determined by SDS-PAGE

Détail du produit

Purification/Conjugué: Cette CD80 protéine est marqué à la His tag.

Fonction: Recombinant Rat CD80/B7-1 Protein (His Tag)

Séquence: Vla30-Gln248

Attributs du produit: Recombinant Rat T-lymphocyte Activation Antigen CD81 is produced by our Mammalian expression system and the target gene encoding Vla30-Gln248 is expressed with a 6His tag at the C-terminus.

niveau d'endotoxine: <1.0 EU per μg as determined by LAL test.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CD80

Autre désignation: CD80/B7-1

Sujet:

Background: Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response.

Synonym: T-lymphocyte activation antigen CD80, Activation B7-1 antigen, B7, CD80

Poids moléculaire: 25.7 kDa

UniProt: O35187

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints