CD80 Protein (CD80) (AA 35-242) (mFc Tag)

N° du produit ABIN7319714

Cette protéine Recombinant CD80 est exprimée dans HEK-293 Cells.

Aperçu rapide pour CD80 Protein (CD80) (AA 35-242) (mFc Tag) (ABIN7319714)

Antigène: CD80

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 35-242

Purification/Conjugué: Cette CD80 protéine est marqué à la mFc Tag.

Fonction: Recombinant Human CD80/B7-1 Protein (mFc Tag)

Séquence: Val35-Leu242

Attributs du produit: Recombinant Human B7-1 Antigen is produced by our Mammalian expression system and the target gene encoding Val35-Leu242 is expressed with a mFc tag at the C-terminus.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: CD80

Autre désignation: CD80/B7-1

Sujet: Activation B7-1 antigen,B7,B7-1,B7.1,BB1,CD28LG,CD28LG1,CD28LGB7-1 antigen,CD80,LAB7,T-lymphocyte activation antigen CD80,Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4. Studies have shown that CTLA-4 binds mostly to CD80. The structure presents two extracellular domains: a membrane distal variable-like domain (IgV) and a membrane proximal Ig constant-like domain (IgC) along with an intracellular domain. Both IgV and IgC consist of anti-parallel beta sandwiches joined by a short linker region. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.

Poids moléculaire:

Calculated MW: 50.5 kDa

Observed MW: 70-95 kDa

ID gène: 941

UniProt: P33681

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints