CD86 Protein (CD86) (Fc Tag)

N° du produit ABIN7320949

Cette protéine Recombinant CD86 est exprimée dans Human Cells.

Aperçu rapide pour CD86 Protein (CD86) (Fc Tag) (ABIN7320949)

Antigène: CD86

Type de proteíne: Recombinant

Origine: Cynomolgus

Source: Human Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette CD86 protéine est marqué à la Fc Tag.

Fonction: Recombinant Cynomolgus B7-2/CD86 Protein (Fc Tag)

Séquence: Ala19-His240

Attributs du produit: Recombinant Cynomolgus CD86 is produced by our Mammalian expression system and the target gene encoding Ala19-His240 is expressed with a Fc tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 100 mM Glycine, pH 7.5.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CD86

Autre désignation: B7-2/CD86

Sujet:

Background: T-lymphocyte activation antigen CD86 (B7-2) is a glycosylated protein in the B7 family. B7 family members are transmembrane cell surface molecules that play important roles in immune activation and the maintenance of immune tolerance. It is highly expressed on activated antigen presenting cells. CD86 involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.

Synonym: T-lymphocyte activation antigen CD86 isoform 1,Activation B7-2 antigen, CD86

Poids moléculaire: 52.5 kDa

UniProt: G7NXR4

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation