ESAM Protéine

N° du produit ABIN7317973

Cette protéine Recombinant ESAM est exprimée dans HEK-293 Cells.

Aperçu rapide pour ESAM Protéine (ABIN7317973)

Antigène: ESAM (Endothelial Cell Adhesion Molecule (ESAM))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: > 92 % as determined by reducing SDS-PAGE.

Détail du produit

Fonction: Recombinant Human ESAM Protein

Séquence: Met 1-Ala 248

Attributs du produit: The mature form of human ESAM (NP_620411.2) extracellular domain (Met 1-Ala 248) with five amino acids (DDDDK) at the C-terminus was expressed and purified.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile 100 mM NaCl, 50 mM Tris, pH 7.5
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: ESAM (Endothelial Cell Adhesion Molecule (ESAM))

Autre désignation: ESAM

Sujet: W117m,Endothelial cell-selective adhesion molecule (ESAM) is a member of JAM family of immunoglobulin superfamily and consists of one V-type and one C2-type immunoglobulin domain, as well as a hydrophobic signal sequence, a single transmembrane region, and a cytoplasmic domain. It is specifically expressed at endothelial tight junctions and on activated platelets. ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. Previous studies have indicated that ESAM regulates angiogenesis in the primary tumor growth and endothelial permeability. It suggest that ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth.

Poids moléculaire:

Calculated MW: 24.5 kDa

Observed MW: 40-45 kDa

ID gène: 90952

NCBI Accession: NP_620411

UniProt: Q96AP7