ESAM Protein (His tag)
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- Antigène Voir toutes ESAM Protéines
- ESAM (Endothelial Cell Adhesion Molecule (ESAM))
- Type de proteíne
- Recombinant
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette ESAM protéine est marqué à la His tag.
- Séquence
- ISLPGPLVTN LLRFLFLGLS ALAPPSRAQL QLHLPANRLQ AVEGGEVVLP AWYTLHGEVS SSQPWEVPFV MWFFKQKEKE DQVLSYINGV TTSKPGVSLV YSMPSRNLSL RLEGLQEKDS GPYSCSVNVQ DKQGKSRGHS IKTLELNVLV PPAPPSCRLQ GVPHVGANVT LSCQSPRSKP AVQYQWDRQL PSFQTFFAPA LDVIRGSLSL TNLSSSMAGV YVCKAHNEVG TAQCNVTLEV STGPGARSHH HHHH
- Attributs du produit
- Chromosomal location: 11q24.2
- Pureté
- > 95 % by SDS-PAGE. Visualized by silver stain
- Top Product
- Discover our top product ESAM Protéine
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- Indications d'application
- No biological data available at the moment.
- Commentaires
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Cytokines & Growth Factors
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Human ESAM should be reconstituted in sterile water to a concentration of 0.1 mg/mL. This solution can be diluted in water or other buffer solutions or stored at -20 °C.
- Buffer
- PBS
- Stock
- 0 °C
- Stockage commentaire
- The lyophilized human ESAM, though stable at room temperature, is best stored desiccated below 0 °C.
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- Antigène
- ESAM (Endothelial Cell Adhesion Molecule (ESAM))
- Autre désignation
- ESAM (ESAM Produits)
- Synonymes
- ESAM Protein, sc:d0254 Protein, W117m Protein, 2310008D05Rik Protein, Esam1 Protein, endothelial cell adhesion molecule Protein, endothelial cell adhesion molecule a Protein, endothelial cell-specific adhesion molecule Protein, ESAM Protein, esama Protein, Esam Protein
- Sujet
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Endothelial cell selective adhesion molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein that belongs to the JAM family of immunoglobulin superfamily molecules. Human ESAM is synthesized as a 390 amino acid (aa) protein composed of a 29 aa signal peptide, a 216 aa extracellular region, a putative 26 aa transmembrane segment, and a 119 aa cytoplasmic domain. The extracellular region contains one V-type and one C2-type Ig domain and is involved in hemophilic adhesion. In the cytoplasmic domain, there is a docking site for the multifunctional adaptor protein MAGI1. The extracellular region of human ESAM shows 90 %, 74%, 69% and 67% aa identity with monkey, canine, mouse and rat extracellular ESAM, respectively. ESAM is expressed on endothelial cells, activated platelets and megakaryocytes, and can be found associated with cell to cell junctions. Whether ESAM is restricted to a particular junctional type is not clear. ESAM deficient mice have no defect in vascularization but do have reduced angiogenic potential. This may be due to a decreased migratory response to FGF2. Soluble ESAM is fused to a C-terminal His-tag (6x His).
Synonyms: ESAM, W117m - Poids moléculaire
- 27.8 kDa
- NCBI Accession
- NM_138961, NP_620411
- UniProt
- Q96AP7
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