ESAM Protein (His tag)

N° du produit ABIN7320087

Détail du produit

Antigène: ESAM (Endothelial Cell Adhesion Molecule (ESAM))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette ESAM protéine est marqué à la His tag.

Fonction: Recombinant Mouse ESAM Protein (His Tag)

Séquence: Met 1-Ala 251

Attributs du produit: A DNA sequence encoding the mouse ESAM (Q925F2) (Met 1-Ala 251) was expressed, with a C-terminal polyhistidine tag.

Pureté: > 92 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: ESAM (Endothelial Cell Adhesion Molecule (ESAM))

Autre désignation: ESAM (ESAM Produits)

Synonymes: ESAM Protein, sc:d0254 Protein, W117m Protein, 2310008D05Rik Protein, Esam1 Protein, endothelial cell adhesion molecule Protein, endothelial cell adhesion molecule a Protein, endothelial cell-specific adhesion molecule Protein, ESAM Protein, esama Protein, Esam Protein

Sujet:

Background: Endothelial cell-selective adhesion molecule (ESAM) is a member of JAM family of immunoglobulin superfamily and consists of one V-type and one C2-type immunoglobulin domain, as well as a hydrophobic signal sequence, a single transmembrane region, and a cytoplasmic domain. It is specifically expressed at endothelial tight junctions and on activated platelets. ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. Previous studies have indicated that ESAM regulates angiogenesis in the primary tumor growth and endothelial permeability. It suggest that ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth.

Synonym: 2310008D05Rik,Esam1,W117m

Poids moléculaire: 25.6 kDa

UniProt: Q925F2