FGF4 Protein (AA 67-202)

N° du produit ABIN7320894

Cette protéine Recombinant FGF4 est produite dans Escherichia coli (E. coli).

Aperçu rapide pour FGF4 Protein (AA 67-202) (ABIN7320894)

Antigène: FGF4 (Fibroblast Growth Factor 4 (FGF4))

Type de proteíne: Recombinant

Origine: Souris

Source: Escherichia coli (E. coli)

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 67-202

Fonction: Recombinant Mouse Fibroblast Growth Factor 4/FGF-4

Séquence: Ser67-Leu202

Attributs du produit: Recombinant Mouse Fibroblast Growth Factor 4 is produced by our E.coli expression system and the target gene encoding Ser67-Leu202 is expressed.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 0.01 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: FGF4 (Fibroblast Growth Factor 4 (FGF4))

Autre désignation: Fibroblast Growth Factor 4/FGF-4

Sujet: FGF-4,FGF4,Fibroblast growth factor 4,HBGF-4,HST,HST-1,HSTF-1,HSTF1,Heparin secretory-transforming protein 1,Heparin-binding growth factor 4,KS3,Transforming protein KS3,Fibroblast growth factor 4(FGF-4) is a heparin binding member of the FGF family. The human FGF4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C-terminus. Mature human FGF4 shares 91 % , 82 %, 94 % and 91 % aa identity with mouse, rat, canine and bovine FGF4, respectively. Human FGF-4 has been shown to exhibit cross species activity. Expression of FGF-4 and its receptors, FGF R1c, 2c, 3c and 4, is spatially and temporally regulated during embryonic development. FGF-4 is proposed to play a physiologically relevant role in human embryonic stem cell selfrenewal. It promotes stem cell proliferation, but may also aid differentiation depending on context and concentration, and is often included in embryonic stem cell media in vitro. FGF-4 is mitogenic for fibroblasts and endothelial cells in vitro and has autocrine transforming potential. It is a potent angiogenesis promoter in vivo and has been investigated as therapy for coronary artery disease.

Poids moléculaire:

Calculated MW: 15.2 kDa

Observed MW: 15 kDa

UniProt: P11403

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance