GRK6 Protein (His-GST)
Aperçu rapide pour GRK6 Protein (His-GST) (ABIN7317064)
Antigène
Voir toutes GRK6 ProtéinesType de proteíne
Activité biologique
Origine
Source
Pureté
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Purification/Conjugué
- Cette GRK6 protéine est marqué à la His-GST.
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Fonction
- Recombinant Human GRK6/GPRK6 Protein (His & GST Tag)
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Séquence
- Met 1-Arg 589
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Attributs du produit
- A DNA sequence encoding the human GRK6 isofrom B (P43250-2) (Met 1-Arg 589) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Stérilité
- 0.2 μm filtered
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niveau d'endotoxine
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- The specific activity was determined to be 7 nmol/min/mg using casein as substrate.
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!Découvrez nos protéines personnalisées prédéfinies et nos services de protéines sur mesure !ProduitSystème d'expressionConjuguéOriginPrix à partir deSystème d'expression HEK-293 CellsConjugué His tagOrigin HumanPrix à partir de 11.737,02 €Système d'expression Cell-free protein synthesis (CFPS)Conjugué Strep TagOrigin HumanPrix à partir de 15.754,29 €Votre projet nécessite-t-il une personnalisation supplémentaire ? Contactez-nous et découvrez nos solutions protéiques sur mesure
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G Protein-Coupled Receptor Kinase 6 (GRK6) (AA 1-576) protein (His tag)
custom-made GRK6 Origine: Souris Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
G Protein-Coupled Receptor Kinase 6 (GRK6) (AA 1-576) protein (His tag)custom-made GRK6 Origine: Humain Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
G Protein-Coupled Receptor Kinase 6 (GRK6) (AA 1-589) protein (GST tag)GRK6 Origine: Humain Hôte: Wheat germ Recombinant WB, ELISA, AA, AP
G Protein-Coupled Receptor Kinase 6 (GRK6) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)GRK6 Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 2 mM GSH, 0.5 mM PMSF, pH 7.4
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Agent conservateur
- PMSF
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Stock
- -20 °C
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Stockage commentaire
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Date de péremption
- 6 months
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- GRK6 (G Protein-Coupled Receptor Kinase 6 (GRK6))
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Autre désignation
- GRK6/GPRK6
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Sujet
- GPRK6,G protein-coupled receptor kinase 6, also known as G protein-coupled receptor kinase GRK6, GRK6 and GPRK6, is a lipid-anchor protein which belongs to theprotein kinase superfamily, AGC Ser/Thr protein kinase family and GPRK subfamily. GRK6 / GPRK6 contains oneAGC-kinase C-terminal domain, oneprotein kinase domain and oneRGS domain. This protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described. GRK6 / GPRK6 is widely expressed. GRK6 / GPRK6 silencing causes suppression of signal transducer and activator of transcription 3 (STAT3) phosphorylation associated with reduction in MCL1 levels and phosphorylation, illustrating a potent mechanism for the cytotoxicity of GRK6 inhibition in multiple myeloma (MM) tumor cells. GRK6 also appears to be involved in responses to morphine. Inhibition of GRK6 represents a uniquely targeted novel therapeutic strategy in human multiple myeloma.
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Poids moléculaire
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Calculated MW: 95.1 kDa
Observed MW: 85 kDa
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ID gène
- 2870
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UniProt
- P43250
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Pathways
- Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Negative Regulation of Transporter Activity
Antigène
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