GNMT Protein (His tag)

N° du produit ABIN7318543

Protéine Recombinant GNMT exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour GNMT Protein (His tag) (ABIN7318543)

Antigène: GNMT (Glycine N-Methyltransferase (GNMT))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette GNMT protéine est marqué à la His tag.

Fonction: Recombinant Human GNMT Protein (His Tag)

Séquence: Met 1-Asg294

Attributs du produit: Recombinant Human Glycine N-Methyltransferase is produced by our E.coli expression system and the target gene encoding Met1-Asg294 is expressed with a 6His tag at the N-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: GNMT (Glycine N-Methyltransferase (GNMT))

Autre désignation: GNMT

Sujet:

Background: Glycine N-Methyltransferase (GNMT) is a tetrameric cytosolic protein. GNMT catalyzes the synthesis of N-methylglycine from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. It can affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine, playing an important role in maintaining normal AdoMet levels. GNMT is highly expressed in liver. As a major folate-binding protein, GNMT takes part in the detoxification pathway. Defects in GNMT are the cause of hypermethioninemia. the patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases.

Synonym: Glycine N-Methyltransferase, GNMT

Poids moléculaire: 34.9 kDa

UniProt: Q14749

Pathways: Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process