KIT Ligand Protein (KITLG) (His tag)

N° du produit ABIN7321261

Protéine Recombinant KIT Ligand exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour KIT Ligand Protein (KITLG) (His tag) (ABIN7321261)

Antigène: KIT Ligand (KITLG)

Type de proteíne: Recombinant

Origine: Rat

Source: Escherichia coli (E. coli)

Pureté: > 95 % as determined by SDS-PAGE

Détail du produit

Purification/Conjugué: Cette KIT Ligand protéine est marqué à la His tag.

Fonction: Recombinant Rat SCF/c-Kit Ligand Protein (E.coli, His Tag)

Séquence: Gln26-Ala189

Attributs du produit: Recombinant Rat Stem Cell Factor is produced by our E.coli expression system and the target gene encoding Gln26-Ala189 is expressed with a 6His tag at the C-terminus.

niveau d'endotoxine: <1.0 EU per μg as determined by LAL test.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: KIT Ligand (KITLG)

Autre désignation: SCF/c-Kit Ligand

Sujet:

Background: Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.

Synonym: FPH2, KIT ligand, Kitl, KITLG, KL-1, Mast cell growth factor, MGF, MGFSHEP7, SCF, SFc-Kit ligand, SLF, steel factor, Stem Cell Factor, c-kit Ligand

Poids moléculaire: 19.3 kDa

UniProt: P21581

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway