LAMP2 Protein (His tag)

N° du produit ABIN7318715

Cette protéine Recombinant LAMP2 est exprimée dans Human Cells.

Aperçu rapide pour LAMP2 Protein (His tag) (ABIN7318715)

Antigène: LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Human Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette LAMP2 protéine est marqué à la His tag.

Fonction: Recombinant Human LAMP2/CD107b Protein (His Tag)(Active)

Séquence: Leu29-Ile375

Attributs du produit: Recombinant Human Lysosome-Associated Membrane Glycoprotein 2 is produced by our Mammalian expression system and the target gene encoding Leu29-Ile375 is expressed with a 6His tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Immobilized Human LGALS3(Cat: PKSH032474) at 1.5μg/ml(100 μl/well) can bind Human LAMP2-His. The ED50 of Human LAMP2-His is 12.73 ug/ml .

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))

Autre désignation: LAMP2/CD107b

Sujet:

Background: Lysosomal Associated Membrane Protein 2 (LAMP2) is a major component of lysosomal membranes. LAMP2 is a transmembrane glycoprotein about 110 kDa. Mature human LAMP2 consists of a 347 amino acid (aa) intralumenal domain, a 24 aa transmembrane segment, and a 35 aa cytoplasmic tail . The lumenal domain is organized into two heavily N-glycosylated regions. Alternate splicing generates a human LAMP2 isoform (LAMP2B) with a substituted juxtamembrane lumenal region, cytoplasmic tail and transmenmbrane segment.LAMP2 itself can cleavage lysosomal luminal domain and degradation lysosomal. In the help of chaperone HSC73,LAMP2 mediates the lysosomal uptake in complex with cargo proteins and is required for the lysosomal destruction of autophagic vacuoles.

Synonym: Lysosome-Associated Membrane Glycoprotein 2, LAMP-2, Lysosome-Associated Membrane Protein 2, CD107 Antigen-Like Family Member B, CD107b, LAMP2

Poids moléculaire: 33.9 kDa

UniProt: P13473

Pathways: Autophagy