SPHK1 Protéine

N° du produit ABIN7317043

Cette protéine Recombinant SPHK1 est produite dans Baculovirus infected Insect Cells.

Aperçu rapide pour SPHK1 Protéine (ABIN7317043)

Antigène: SPHK1 (Sphingosine Kinase 1 (SPHK1))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Baculovirus infected Insect Cells

Pureté: > 85 % as determined by reducing SDS-PAGE.

Détail du produit

Fonction: Recombinant Human SPHK1/Sphingosine Kinase 1 Protein (Active)

Séquence: Met 1-Leu 384

Attributs du produit: A DNA sequence encoding the human SPHK1 (Q9NYA1-1)(Met1-Leu384) was fused with two additional amino acids (Gly & Pro) at the N-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 1028 nmol/min/mg using Sphingosine Kinase Substrate as substrate.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: SPHK1 (Sphingosine Kinase 1 (SPHK1))

Autre désignation: SPHK1/Sphingosine Kinase 1

Sujet:

Background: SPHK1, also known as sphingosine Kinase 1, catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It is a ligand for cell surface G protein-coupled receptors. SPHK 1 is a potential therapeutic target for the control of cancer and inflammation. SPHK1 plays a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes.

Synonym: SPHK,SPHK1,SPK

Poids moléculaire: 42.7 kDa

Pathways: VEGF Signaling