FGFR4 Protein (AA 22-369) (His tag)

N° du produit ABIN7274612

Protéine Recombinant FGFR4 exprimée dans HEK-293 Cells.

Aperçu rapide pour FGFR4 Protein (AA 22-369) (His tag) (ABIN7274612)

Antigène: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Macaque rhésus

Source: HEK-293 Cells

Pureté: > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC

Détail du produit

Attributs du protein: AA 22-369

Purification/Conjugué: Cette FGFR4 protéine est marqué à la His tag.

Fonction: Rhesus macaque FGFR4 Protein

Séquence: Leu22-Asp369

Attributs du produit: Recombinant Rhesus macaque FGFR4 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu22-Asp369.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1 EU per μg by the LAL method.

Biological Activity Comment: Rhesus macaque FGFR4 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.,The purity of Rhesus macaque FGFR4 is greater than 95% as determined by SEC-HPLC.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1 mg/mL for 500 μg or 1 mg lyophilized powder. Do not mix by vortex or vigorous shaking.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3 months after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Autre désignation: FGFR4

Sujet: Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19.

Poids moléculaire: 39.66 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.

NCBI Accession: XP_028705775

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding