CD80 Protein (CD80) (Biotin,Fc-Avi Tag)

N° du produit ABIN7316777

Cette protéine Recombinant CD80 est exprimée dans HEK-293 Cells.

Aperçu rapide pour CD80 Protein (CD80) (Biotin,Fc-Avi Tag) (ABIN7316777)

Antigène: CD80

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: 95,00 %

Classe de qualité: MALS verified

Détail du produit

Purification/Conjugué: Cette CD80 protéine est marqué à la Biotin,Fc-Avi Tag.

Fonction: Biotinylated Human B7-1 / CD80 Protein, Fc,Avitag™ (MALS verified)

Séquence: Val 35 - Asn 242

Attributs du produit: Biotinylated Human B7-1 / CD80,Fc,Avitag is expressed from human 293 cells (HEK293). It contains AA Val 35 - Asn 242 (Accession # P33681-1).

niveau d'endotoxine: 1.0 EU per μg

Information d'application

Commentaires:

This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 52.0 kDa. The protein migrates as 65-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris,100 mM Glycine,25 mM Arginine,150 mM NaCl, pH 7.5

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: CD80

Autre désignation: B7-1

Sujet: Synonyms:CD80,B7,B7-1,B7.1,BB1,CD28LG,CD28LG1,LAB7,Description:B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20 - 100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

Poids moléculaire: 52.0 kDa

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints