GDNF Protéine

N° du produit ABIN7488782

Protéine Recombinant GDNF exprimée dans HEK-293 Cells.

Aperçu rapide pour GDNF Protéine (ABIN7488782)

Antigène: GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: 90 %

Classe de qualité: Premium grade

Détail du produit

Fonction: Human GDNF / ATF / hGDNF Protein, premium grade

Séquence: Ser 78 - Ile 211

Attributs du produit: Human GDNF Protein, premium grade is expressed from human 293 cells (HEK293). It contains AA Ser 78 - Ile 211 (Accession # P39905-1).

niveau d'endotoxine: 0.1 EU per μg

Information d'application

Commentaires:

This protein carries no "tag". () The protein has a calculated MW of 15.1 kDa. The protein migrates as 15-22 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))

Autre désignation: GDNF

Sujet: Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. The GDNF family members (consists of GDNF, neurturin, artemin and persephin) are structurally similar to transforming growth factor-beta. Unlike other members of the TGF-beta superfamily, which signal through the receptor serine-threonine kinases, GDNF family ligands activate intracellular signalling cascades via the receptor tyrosine kinase Ret. GDNF family ligands binds to GDNF family receptor alpha (GFRalpha) and then the GDNF family ligand-GFR alpha complex binds to and stimulates autophosphorylation of Ret.

Poids moléculaire: 15.1 kDa

Pathways: Signalisation RTK, Synaptic Membrane, Tube Formation, Autophagy, Smooth Muscle Cell Migration