Angiopoietin 2 Protein (ANGPT2) (His tag)

N° du produit ABIN7488954

Cette protéine Recombinant Angiopoietin 2 est produite dans HEK-293 Cells.

Aperçu rapide pour Angiopoietin 2 Protein (ANGPT2) (His tag) (ABIN7488954)

Antigène: Angiopoietin 2 (ANGPT2)

Type de proteíne: Recombinant

Origine: Lapin

Source: HEK-293 Cells

Pureté: 95 %

Classe de qualité: MALS verified

Détail du produit

Purification/Conjugué: Cette Angiopoietin 2 protéine est marqué à la His tag.

Fonction: Rabbit Angiopoietin-2 / ANGPT2 Protein, His Tag (MALS verified)

Séquence: Lys 275 - Phe 496

Attributs du produit: Rabbit Angiopoietin-2 Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Lys 275 - Phe 496 (Accession # G1T9B3-1).

niveau d'endotoxine: 1.0 EU per μg

Information d'application

Commentaires:

This protein carries a polyhistidine tag at the C-terminus. (10xHis) The protein has a calculated MW of 27.4 kDa. The protein migrates as 30-34 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 20 mM MOPS, 5 mM CHAPS, 150 mM NaCl, pH 7.5

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: Angiopoietin 2 (ANGPT2)

Autre désignation: Angiopoietin-2

Sujet: Angiopoietin-2 is also known as ANGPT2, AGPT2, ANG2, and is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Ang2 is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the placenta, ovaries, and uterus. It is particularly abundant in vascular endothelial cells (EC) where it is stored in intracellular Weibel Palade bodies. Both Ang2 and the related Angiopoietin1 (Ang1) are ligands for the receptor tyrosine kinase Tie 2. Ang2 functions as a proangiogenic factor, although it can also induce EC death and vessel regression. Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. Ang2 is required for postnatal vascular remodeling, and it cooperates with Ang1 during lymphatic vessel development. It mediates the upregulation of ICAM1 and VCAM1 on EC, which facilitates the adhesion of leukocytes during inflammation. Ang2 competitively inhibit Ang1-induced endothelial cell responses mediated by Tie2, and reduces vascular integrity. But the role of Ang2 is controversial since the opposite outcomes has been reported in other studies. Over-expression of Ang2 disrupts the vascular remodeling, induce endothelial cell apoptosis, and may play an important regulating role in tumor angiogenesis. Ang2 also promotes the neuronal differentiation and migration of subventricular zone progenitor cells.

Poids moléculaire: 27.4 kDa

Pathways: Signalisation RTK