CD8 alpha Protein (Fc Tag)

N° du produit ABIN7535717

Protéine Recombinant CD8 alpha exprimée dans HEK-293 Cells.

Aperçu rapide pour CD8 alpha Protein (Fc Tag) (ABIN7535717)

Antigène: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Pureté: > 95 % by SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette CD8 alpha protéine est marqué à la Fc Tag.

Fonction: Recombinant Mouse CD8a Protein

Séquence: KPQAPELRIF PKKMDAELGQ KVDLVCEVLG SVSQGCSWLF QNSSSKLPQP TFVVYMASSH NKITWDEKLN SSKLFSAMRD TNNKYVLTLN KFSKENEGYY FCSVISNSVM YFSSVVPVLQ KVNSTTTKPV LRTPSPVHPT GTSQPQRPED CRPRGSVKGT GLDFACDIY

Specificité: Lys28-Tyr196

Stérilité: 0.22 μm filtered

niveau d'endotoxine: <0.1EU/μg

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C,-80 °C

Stockage commentaire: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Détail du antigène

Antigène: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Autre désignation: CD8a

Sujet:

Description: T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

Name: Ly-2, Ly-B, Ly-35, Lyt-2,CD8A

ID gène: 12525

UniProt: P01731

Pathways: TCR Signaling