IGF1 Protéine

N° du produit ABIN7680475

Cette protéine Recombinant IGF1 est produite dans Escherichia coli (E. coli).

Aperçu rapide pour IGF1 Protéine (ABIN7680475)

Antigène: IGF1 (Insulin-Like Growth Factor 1 (IGF1))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Application: Cell Culture (CC)

Pureté: More than 95 % as determined by SDS-PAGE. 

Classe de qualité: Animal-Free

Détail du produit

Fonction: rIGF-1 LR3 - Recombinant human Insulin-like growth factor-1 LR3

Attributs du produit: This product arrives as White lyophilized powder 

niveau d'endotoxine: Less than 5 EU/mg

Biological Activity Comment: The bioactivity determined by a cell proliferation assay using Balb/c 3T3 cell, corresponding to a specific activity of ≥ 1x10^6 Units/mg.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is recommended to reconstitute LR3 IGF-1 at 100-200 μg/mL in sterile water.

Buffer: It is lyophilized with mannitol as the stabilizer.

Conseil sur la manipulation: Use as soon as possible after opening. Avoid freeze-thaw cycles

Stock: -20 °C

Stockage commentaire: Stored at temperatures -20°C for at least 36 months. Further dilutions can be made in other aqueous buffer. Use as soon as possible after opening. Please avoid freeze-thaw cycles.

Date de péremption: 36 months

Détail du antigène

Antigène: IGF1 (Insulin-Like Growth Factor 1 (IGF1))

Autre désignation: Insulin-like growth factor-1

Sujet: Insulin-like growth factor-1 (IGF-1) is a hormone similar in molecular structure to insulin. It primarily functions through binding to its specific receptor, the insulin-like growth factor 1 receptor (IGF1R). IGF-1 is one of the most potent natural activators of the AKT signaling pathway, which stimulates cell growth and proliferation, and inhibits cell apoptosis. LR3 IGF-1 (Long Arg3 IGF-1) is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus. The LR3 IGF-1 has much higher stability and biological activity.

Poids moléculaire: 9.1kD

Pathways: Signalisation RTK, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Hormone Activity, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Activated T Cell Proliferation, Positive Regulation of fat Cell Differentiation