CDK1 Protéine

N° du produit ABIN7938734

Protéine Recombinant CDK1 exprimée dans Baculovirus infected Insect Cells.

Aperçu rapide pour CDK1 Protéine (ABIN7938734)

Antigène: CDK1 (Cyclin-Dependent Kinase 1 (CDK1))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Détail du produit

Fonction: Recombinant CDK1 protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Recombinant CDK1 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Détail du antigène

Antigène: CDK1 (Cyclin-Dependent Kinase 1 (CDK1))

Autre désignation: CDK1

Sujet:

Protein Background: CDK1 (Cyclin-dependent kinase 1) , also known as CDC2, CDC28A and P34CDC2. CDK1 plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset, promotes G2-M transition via association with multiple interphase cyclins. Associated with its cognate partner cyclin B, is a key enzyme for entry in mitosis and is essential for spindle morphogenesis. CDK1 up-regulates microtubule dynamics when added in cell free Xenopus extracts. CDK1inactivation is necessary for proper anaphase spindle dynamics and for cytokinesis. Large amounts of CDK1 induce the depolymerization of interphase microtubules when injected into mammalian cells and the destabilization of microtubule arrays when added on lysed mammalian cells.

Short Description: Recombinant CDK1 protein was expressed in a baculovirus expression system as the full-length protein (accession number NP_001777.1) with an C-terminal FLAG tag. The molecular weight of CDK1 is 35.79 kDa.

Aliases: CDC2, CDC28A, P34CDC2, Cell Division Protein Kinase 1, CDKN1, P34 Protein Kinase Cyclin-Dependent Kinase 1

Pathways: Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Toll-Like Receptors Cascades, Synthesis of DNA