E2F1 Protéine

N° du produit ABIN7938780

Cette protéine Recombinant E2F1 est produite dans Human.

Aperçu rapide pour E2F1 Protéine (ABIN7938780)

Antigène: E2F1 (E2F Transcription Factor 1 (E2F1))

Type de proteíne: Recombinant

Origine: Humain

Source: Human

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Détail du produit

Fonction: Recombinant E2F1 protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Recombinant E2F1 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Détail du antigène

Antigène: E2F1 (E2F Transcription Factor 1 (E2F1))

Autre désignation: E2F1

Sujet:

Protein Background: E2F1 is a transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/ p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters.

Short Description: Recombinant E2F1 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_005216.1) with an N-terminal FLAG tag. The molecular weight of E2F1 is 48.19 kDa.

Aliases: E2F Transcription Factor 1, RBBP3, RBP3, Transcription Factor E2F1, RBAP-1, E2F-1, PBR3

Pathways: Signalisation p53, Cycle Cellulaire, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Autophagy