EPH Receptor A4 Protein (EPHA4) (AA 570-986)

N° du produit ABIN7938798

Cette protéine Recombinant EPH Receptor A4 est produite dans Baculovirus infected Insect Cells.

Aperçu rapide pour EPH Receptor A4 Protein (EPHA4) (AA 570-986) (ABIN7938798)

Antigène: EPH Receptor A4 (EPHA4)

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Application: Screening Assay (ScA), Functional Studies (Func), Activity Assay (AcA)

Détail du produit

Attributs du protein: AA 570-986

Fonction: Recombinant EPHA4 (570-986) protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Recombinant EPHA4 (570-986) protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Détail du antigène

Antigène: EPH Receptor A4 (EPHA4)

Autre désignation: EPHA4

Sujet:

Protein Background: EPHA4 (Ephrin type-A receptor 4) is a receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, also plays a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation.

Short Description: Recombinant EPHA4 (570-986) protein that includes amino acids 570-986 of human EPHA4 protein (accession number NP_001291465.1) was expressed in a baculovirus expression system and contains an N-terminal FLAG tag. The molecular weight of the protein is 48.46 kDa.

Aliases: Ephrin type-A receptor 4, EPH Receptor A4, HEK8, TYRO1, Tyrosine-Protein Kinase Receptor SEK, EK8

Pathways: Signalisation RTK