EPH Receptor B1 Protein (EPHB1) (AA 565-984)

N° du produit ABIN7938802

Cette protéine Recombinant EPH Receptor B1 est exprimée dans Baculovirus infected Insect Cells.

Aperçu rapide pour EPH Receptor B1 Protein (EPHB1) (AA 565-984) (ABIN7938802)

Antigène: EPH Receptor B1 (EPHB1)

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Détail du produit

Attributs du protein: AA 565-984

Fonction: Recombinant EPHB1 (565-984) protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Recombinant EPHB1 (565-984) protein is supplied in 25 mM HEPESNaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100 and 0.5 mM TCEP.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Stock: -80 °C

Stockage commentaire: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Détail du antigène

Antigène: EPH Receptor B1 (EPHB1)

Autre désignation: EPHB1

Sujet:

Protein Background: EPHB1(Ephrin type-B receptor 1) is a receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their selfrenewal and reducing their activation and differentiation (By similarity).

Short Description: Recombinant EPHB1 (565-984) protein that includes amino acids 565-984 of human EPHB1 protein (accession number NP_004432.1) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 48.78 kDa.

Aliases: Ephrin type-B receptor 1, EPHT2, HEK6, ELK, NET, EK6, Eph Tyrosine Kinase

Pathways: Signalisation RTK